Modeling of Glucose-Insulin System Dynamics in Diabetic Goettingen Minipigs

Development of an artificial pancreas which regulates blood glucose in a closed loop framework is the ultimate goal in the treatment of diabetes. Development of a model which captures the glucose-insulin dynamic is a mandatory step prior to the in vivo-test and validation of a feedback controller. Towards this end, the focus of this paper is on the development of a glucose-insulin model for diabetic Goettingen minipigs, which will serve as a proxy for human testing of a blood glucose regulator. This paper presents an eighth-order model to capture the glucose-insulin dynamics in diabetic Goettingen minipigs. Comparison of the measurement data with the calculated evolution of the blood glucose trajectories illustrates satisfactory results providing a basis of optimism for the ultimate implementation of a closed loop controller.