Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7206906 | Journal of the Mechanical Behavior of Biomedical Materials | 2018 | 9 Pages |
Abstract
β-tricalcium phosphate (β-TCP) bioceramic, which is a prevalent bone graft, is deficient in mechanical strength and mediating the biological functions. In the present study, β-tricalcium phosphate composite bioceramics (TCP/SPNs) were prepared by introducing SrO-P2O5-Na2O based (SPN) sintering additive. With increasing mole ratio of SrO to P2O5, the SPN tended to crystallize. In the liquid-phase sintering process, β-TCP reacted with SPN, producing new compounds. The difference in characteristic of SPN additive affected the compressive strength and cell-biological response of the fabricated TCP/SPNs. By selecting SPN with appropriate formulation, the TCP/SPNs not only could more than double their compressive strength, but also improved the cell viability, promoted osteogenic differentiation and inhibited osteoclastic activities. Taken together, this work establishes a beneficial strategy to improve the overall performance of calcium phosphate bioceramic for application in bone regeneration.
Related Topics
Physical Sciences and Engineering
Engineering
Biomedical Engineering
Authors
Fupo He, Teliang Lu, Ye Tian, Xue Li, Fei Zuo, Xuetao Shi, Jiandong Ye,