Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7207781 | Journal of the Mechanical Behavior of Biomedical Materials | 2016 | 12 Pages |
Abstract
The microscopic studies conducted on scoliotic annulus fibrosus showed a significant architectural distortion of collagen and elastin fibres. Quantitative biochemical assays demonstrated region-dependent distribution of only collagen types I and II in the case of healthy intervertebral discs whereas in the case of scoliotic discs region-dependent distribution concerned all examined proteins of the extracellular matrix. Comparison of scoliotic and healthy annulus fibrosus revealed a significant decrease in the content of collagen type I and elastin as well as a slight increase in the proportion of collagen types III and IV. The content of collagen type II did not differ significantly between both groups. The observed anomalies are a manifestation of degenerative changes affecting annulus fibrosus of the intervertebral disc in patients suffering from scoliosis.
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Authors
Magdalena Kobielarz, Sylwia Szotek, Maciej GÅowacki, Joanna Dawidowicz, Celina Pezowicz,