Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7208155 | Journal of the Mechanical Behavior of Biomedical Materials | 2016 | 48 Pages |
Abstract
In a numerical verification experiment, we have shown the feasibility of identifying nonlinear and orthotropic constitutive behaviour based on the observation of just two load cases, even though the load free geometry is unknown, if heterogeneous strain fields are available. Only clinically available 4D US measurements of wall motion and diastolic and systolic blood pressure are required as input for the inverse FE updating approach. Application of the developed inverse approach to 4D US data sets of three aortic wall segments from volunteers of different age and pathology resulted in the reproducible identification of three distinct and (patho-) physiologically reasonable constitutive behaviours. The use of patient-individual material properties in biomechanical modelling of AAAs is a step towards more personalized rupture risk assessment.
Related Topics
Physical Sciences and Engineering
Engineering
Biomedical Engineering
Authors
Andreas Wittek, Wojciech Derwich, Konstantinos Karatolios, Claus Peter Fritzen, Sebastian Vogt, Thomas Schmitz-Rixen, Christopher Blase,