Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7211406 | Beni-Suef University Journal of Basic and Applied Sciences | 2018 | 4 Pages |
Abstract
Pumpkin seeds (Cucurbita pepo) and Pomegranate peel (Punica granatum) have anthelmintic properties. The aim of this study was to compare the anthelmintic efficacy of pumpkin seeds ethanolic extract and pomegranate peel aqueous extract against Ascaridia galli in vitro and in vivo in Baladi chicks. On adult worms, the extracts of the two herbs were compared in vitro at concentrations of 25, 50, and 75â¯mg/ml with fenbendazole at a concentration of 5â¯mg/ml. Chicks were infected with Ascaridia galli eggs containing second stage larva and treated with 2000â¯mg/kg of each of the extracts compared with 100â¯mg/kg fenbendazole. In vitro, all concentrations of pumpkin seed extract and the concentration of 75â¯mg/ml pomegranate peel extract exhibited a nearly similar effect to fenbendazole. In vivo, the mortality rate of the worms extracted from the 2000â¯mg/kg pumpkin seeds extract-treated chicken was non-significantly different from that of fenbendazole for 48â¯h. While pomegranate peels extract exhibited a lower lethal effect than fenbendazole. The anthelmintic efficacy was dependent on time and concentration. The study presented the anthelmintic efficacy of the pumpkin seeds and pomegranate peel extracts on Ascaridia galli. Pumpkin seed extract was more effective than pomegranate peel extract. Future studies to determine the optimal dose to maximize their effectiveness especially for pumpkin seeds as anthelmintic therapeutic are required.
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Authors
Amer R. Abdel Aziz, Mahmoud R. AbouLaila, Mohammad Aziz, Mosaab A. Omar, Khaled Sultan,