Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7211433 | Beni-Suef University Journal of Basic and Applied Sciences | 2018 | 7 Pages |
Abstract
Polymorphisms of the renin-angiotensin system genes influence the pathogenesis of atherosclerosis and are connected with heart diseases. We explore the potential associations of ACE (I/D) and AGT (M235T) gene polymorphisms with coronary artery disease (CAD). A total of one hundred and twenty Egyptian patients (Sixty with CAD and sixty without CAD) and fifty healthy control subjects were included in the study. Genotyping of ACE (I/D) and AGT (M235T) were analyzed by the polymerase chain reaction (PCR) technique. Serum lipid profiles (total cholesterol, triglyceride, HDL-C) were measured by the enzymatic colorimetric method. Our data showed that the ACE D allele frequency (PÂ <Â 0.0001; odds ratio [OR]Â =Â 2.538, 95% confidence interval [CI]Â =Â 1.468-4.388), DD genotype (PÂ <Â 0.0001, ORÂ =Â 0.239, 95% CIÂ =Â 0.066-0.866), the frequency of AGT T allele (PÂ <Â 0.0001, ORÂ =Â 2.915, 95% CIÂ =Â 1.666-5.097) and TT genotype (PÂ <Â 0001, ORÂ =Â 0.316, 95% CIÂ =Â 0.078-1.280) were significantly more prevalent among CAD patients and may be predisposing to CAD. We further found that the concomitant presence of the ACE-DD and AGT-TT genotypes increased the risk of CAD (PÂ =Â 0.017, ORÂ =Â 0.120, 95% CIÂ =Â 0.042-0.347). This study demonstrated the contribution of ACE (I/D) and AGT (M235T) gene polymorphisms individually or in combination to the presence of CAD risk in the Egyptian population. The ACE D allele and AGT T allele may be predictive in individuals at risk of developing CAD.
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Authors
Ibrahim H. Borai, Nahla S. Hassan, Olfat G. Shaker, Esmat Ashour, Mohammed E.l. Badrawy, Olfat M. Fawzi, Lamiaa Mageed,