| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7228877 | Biosensors and Bioelectronics | 2018 | 21 Pages |
Abstract
Novel cathodic photoelectrochemical (PEC) aptasensors for sensitive and selective determination of thrombin and Pb2+ were developed based on a new dual-signal amplification strategy. The presence of gold nanoparticles (AuNPs) could quench the PEC signal of bismuth oxyiodide (BiOI). At the same time, the redox moiety G-quadruplex/hemin or ferrocene (Fc) was found to enhance the PEC signal of BiOI. So, in the presence of thrombin or Pb2+, the interaction between target and the aptamer resulted in the releasement of the AuNPs, as well as shorter distance between the redox moiety and the electrode surface. Hence dual-enhanced cathodic PEC biosensor strategy was realized. Under the optimized conditions, the detection limits of thrombin and Pb2+ were 17.3â¯fM and 3.16â¯pM, respectively with good selectivity. At the same time, the PEC performance of redox moiety G-quadruplex/hemin and Fc was compared.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ying Li, Fengting Chen, Zhenzhu Luan, Xiaoru Zhang,