Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7229327 | Biosensors and Bioelectronics | 2018 | 7 Pages |
Abstract
A novel carbon nanocomposite paste electrode was prepared and used as a voltammetric sensor for ultratrace determination of trimipramine (TRI) which currently used for the treatment of psychiatric disorders. For this aim, nanoparticles of molecularly imprinted polymer (MIP), synthesized by precipitation polymerization method, and multi-walled carbon nanotubes (MWCNTs) were embedded in a nanocomposite paste electrode. The nanocomposite mixing style demonstrated a significant influence on the final electrode performance. The sensor exhibited linear response range of 1.0â¯Ãâ¯10â10-2.5â¯Ãâ¯10â8 molâ¯Lâ1 and very high sensitivity of 2131â¯Î¼Aâ¯Î¼â¯molâ¯Lâ1. The lower detection limit of the sensor was calculated to be 4.5â¯Ãâ¯10-11 molâ¯Lâ1 (S/Nâ¯=â¯3). This sensor was applied successfully for highly selective determination of TRI in pharmaceutical formulations, urine and serum samples without applying any sample pretreatment.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Maedeh Akhoundian, Taher Alizadeh, Mohammad Reza Ganjali, Faride Rafiei,