Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7231146 | Biosensors and Bioelectronics | 2016 | 9 Pages |
Abstract
We developed a strip biosensors array based on aptamer-modified gold nanoparticles as receptors and combined the protein-aptamer binding reaction with the streptavidin-biotin interaction as well as the sandwich format. We found that a series of protein receptors obtained a distinct response pattern to each target protein. Three proteins have been well distinguished with the naked eyes and a portable reader without mutual interference, accompanying with lower limit of detection and wider linear range. A complete set of four elementary logic gates (AND, OR, INH, and NAND) and eight combinative logic gates (AND-OR; AND-INH; OR-INH; INH-NAND; AND-OR-INH; AND-INH-NAND; OR-INH-NAND; AND-OR-INH-NAND) are thoroughly realized using this array, which could eventually be applicable to the keypad-lock system with enhanced complexity in the near future. Moreover, this array shows excellent linear relationships, anti-interference capability, real human serum samples applicability, long-term storage stability and reproducibility. All indicate that this design has very good prospects for development.
Related Topics
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Authors
Chunyan Qin, Ya Gao, Wei Wen, Xiuhua Zhang, Shengfu Wang,