Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7231863 | Biosensors and Bioelectronics | 2015 | 6 Pages |
Abstract
A new strategy for a composite film based electrochemical sensor was developed in this work. A layer of conductive film of poly(p-aminobenzene sulfonic acid) (pABSA) was electropolymerized onto glassy carbon electrode surface and exhibited a high electrocatalytic active for paracetamol (PR) redox. The subsequent formation of a layer of molecular imprinted polymer (MIP) film on pABSA modified electrode endowed the sensor with plentiful imprinted cavities for PR specific adsorption. The advantages of the composite film made the prepared sensor display high sensitivity and good selectivity for PR detection and recognition. Under the optimal conditions, the sensor could recognize PR from its interferents. A linear ranging from 5.0Ã10â8 to 1.0Ã10â4Â mol/L for PR detection was obtained with a detection limit of 4.3Ã10â8Â mol/L. The sensor has been applied to analyze PR in tablets and human urine samples with satisfactory results. The simple, low cost, and efficient strategy reported here can be further used to prepare electrochemical sensors for other compounds recognition and detection.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Ying Teng, Limei Fan, Yunlong Dai, Min Zhong, Xiaojing Lu, Xianwen Kan,