Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7232132 | Biosensors and Bioelectronics | 2015 | 6 Pages |
Abstract
Considerable recent attention has been paid to homogeneous fluorescent DNA detection with the use of nanostructures as a universal “quencher”, but it still remains a great challenge to develop such nanosensor with the benefits of low cost, high speed, sensitivity, and selectivity. In this work, we report the use of iron-based metal-organic framework nanorods as a high-efficient sensing platform for fluorescent DNA detection. It only takes about 4Â min to complete the whole “mix-and-detect” process with a low detection limit of 10Â pM and a strong discrimination of single point mutation. Control experiments reveal the remarkable sensing behavior is a consequence of the synergies of the metal center and organic linker. This work elucidates how composition control of nanostructures can significantly impact their sensing properties, enabling new opportunities for the rational design of functional materials for analytical applications.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jingqi Tian, Qian Liu, Jinle Shi, Jianming Hu, Abdullah M. Asiri, Xuping Sun, Yuquan He,