Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7232680 | Biosensors and Bioelectronics | 2015 | 25 Pages |
Abstract
We developed a silicon nanowire based electrical cell impedance sensor (SiNW-ECIS) as an instrument that detects cancerous cultured living lung cells by monitoring their spreading state at which the cells stretched and become extended on nanowires. Further current penetration into the extended membrane of malignant cells in respect to normal ones (In the first 6Â h after cells interaction with surface) are the key mechanism in our diagnosis procedure. The developed device applied to monitor the spreading-induced electrical differences between cancerous and normal lung cells in an integral fashion. Detection was performed so faster than the time required to complete cells mitosis. Morphology and architecture of doped Si nanowires covered microelectrodes observably enhance the contact area between cells and electrodes which support accurate signal recording from stretched cells as indicated by SEM and florescent images.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Hamed Abiri, Mohammad Abdolahad, Milad Gharooni, Seyed Ali Hosseini, Mohsen Janmaleki, Soheil Azimi, Mohammad Hosseini, Shams Mohajerzadeh,