Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7233523 | Biosensors and Bioelectronics | 2014 | 6 Pages |
Abstract
A novel optical detection method for hemoglobin concentration is described. The hemoglobin molecules consisting mainly of iron generate heat upon their absorption of light energy at 532Â nm, which subsequently changes the refractive index of the blood. We exploit this photothermal effect to determine the hemoglobin concentration of erythrocytes without any preprocessing of blood. Highly sensitive measurement of refractive index alteration of blood samples is enabled by a spectral-domain low coherence reflectometric sensor with subnanometer-level optical path-length sensitivity. The performance and validity of the sensor are presented by comparing the measured results against the reference data acquired from an automatic hematology analyzer.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Jinyeong Yim, Hun Kim, Suho Ryu, Sungwook Song, Hyun Ok Kim, Kyung-A Hyun, Hyo-Il Jung, Chulmin Joo,