| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 723354 | IFAC Proceedings Volumes | 2006 | 6 Pages |
Abstract
The dynamics of non-esterified free fatty acids (FFA) during modified intravenous glucose tolerance test (IVGTT) is studied. The first step is to formulate a physiological model suitable to describe FFA kinetics. A single compartment model is utilized, with FFA production controlled by insulin in a remote compartment and indirectly by intracellular glucose. Then, from the analysis of the experimental data, the kinetic parameters of the model are estimated using a population modelling approach and their dependence upon individual characteristics is investigated. The proposed model is a promising tool for investigating the relationship between glucose and lipid metabolism and their control by insulin.
Keywords
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Physical Sciences and Engineering
Engineering
Computational Mechanics
Authors
Alessandra Pavan, Karl Thomaseth, Giovanni Pacini, Attila Brehm, Michael Roden,