Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7233598 | Biosensors and Bioelectronics | 2014 | 8 Pages |
Abstract
This work demonstrates the feasibility of employing SNA-I to selectively recognize the STn epitope in glycoproteins and the use of the constructed biosensor was effective in the analysis of serum samples with the ability to discriminate in a fast way between cancer and healthy status. The proposed biosensor could be used for high-throughput, label-free profiling of the cancer-associated STn glycan expression in serum for diagnosis and therapy monitoring.
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
M. LuÃsa S. Silva, Evelin Gutiérrez, José A. RodrÃguez, Catarina Gomes, Leonor David,