| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7234584 | Biosensors and Bioelectronics | 2013 | 6 Pages |
Abstract
⺠A novel label-free SPR-based aptasensor for thrombin detection was developed and characterized. ⺠This approach was based on the modification of a gold surface with 4-mercaptobenzoic acid, streptavidin and biotinylated anti-thrombin aptamer. ⺠The quantification of thrombin was performed from changes in the SPR angle. ⺠The biosensing platform demonstrated to be highly selective and sensitive for human thrombin with a detection limit of 12.0 nmol Lâ1 (240 fmol in the sample).
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Authors
Yamile Jalit, Fabiana A. Gutierrez, Galina Dubacheva, Cedric Goyer, Liliane Coche-Guerente, Eric Defrancq, Pierre Labbé, Gustavo A. Rivas, Marcela C. RodrÃguez,