Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7234742 | Biosensors and Bioelectronics | 2013 | 6 Pages |
Abstract
Finally, an electrochemical transduced biosensor has been realized, based on the reaction of vitamin D with 4-ferrocenylmethyl-1,2,4-triazoline-3,5-dione (FMTAD): once derivatized, the determination of 25OHD was possible in the range 20-200Â ng/ml with a LOD of 10Â ng/ml. The latter proposed system fits the requirement of determining vitamin D in a concentration range which is of significance for clinical applications; moreover, since a screen printed electrode has been used, this opens the possibility to miniaturize the sensor and developing a portable and easy-to-automate point-of-care testing device. The proposed devices provide an improvement with respect to traditional methods that are time and reagents consuming and require radioactive compounds, pretreatment procedures and expensive instrumentation.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Analytical Chemistry
Authors
Luciano Carlucci, Gabriele Favero, Cristina Tortolini, Massimo Di Fusco, Elisabetta Romagnoli, Salvatore Minisola, Franco Mazzei,