Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7234938 | Biotechnology Reports | 2018 | 4 Pages |
Abstract
The Lippia alba (Mill.) N.E. Brown (Verbenaceae) species, has effects sedative, analgesic and spasmolytic properties. This study had as its main objective to evaluate the essential oil of L. alba (EOLa) effect and that of its main constituents, citral and limonene, over tracheal smooth muscle from Wistar rats. EOLa, citral and limonene promoted relaxation of tracheal smooth muscle in contractions induced by potassium (60â¯mMâ¯K+), presenting an EC50 of 148â¯Â±â¯7â¯Î¼g/mL for the EOLa, 136â¯Â±â¯7â¯Î¼g/mL for citral and 581â¯Â±â¯7â¯Î¼g/mL for limonene. In contractions induced by Acetylcholine (Ach; 10â¯Î¼M) the EC50 for the EOLa and citral were of 731â¯Â±â¯5â¯Î¼g/mL and 795â¯Â±â¯9â¯Î¼g/mL, respectively. In preparations pre-incubated with 1000â¯Î¼g/mL of the EOLa and citral, both agents were found to block the influx of BaCl2 by VOCCs. This study demonstrated that the EOLa and its main component citral present antispasmodic effect over tracheal smooth muscle of rats.
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Authors
Poliana M.M. Carvalho, CÃcero A.F. Macêdo, Tiago F. Ribeiro, Andressa A. Silva, Renata E.R. Da Silva, LuÃs P. de Morais, Marta R. Kerntopf, Irwin R.A. Menezes, Roseli Barbosa,