INFLAM - INFLAMmation in Brain and Vessels with Iron Nanoparticles and Cell Trafficking: A Multiscale Approach of Tissue Microenvironment, Iron Nanostructure and Iron Biotransformation

- USPIOs seem to benefit from the endogenous iron metabolism to minimize toxicity.
- USPIOs-labeled macrophages can be followed into the plaque up to 3 days after injection.
- Passive leakage of USPIOs through compromised barriers may occur after focal cerebral Ischemia.
- USPIO-MRI allows to quantitatively monitor immunomodulatory effects after stroke onset.