| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7238749 | Nanomedicine: Nanotechnology, Biology and Medicine | 2018 | 41 Pages |
Abstract
A novel chemotherapeutic (CDDP)-siRNA (HuR) combination was tested for its anti-tumor efficiency in lung cancer cells using folic acid conjugated Dendrimer-Polyethlyeneimine (Den-PEI) nanoparticles. This Den-PEI-CDDP-HuR-FA system showed favorable properties for targeted delivery and enhanced cell uptake in folate receptor alpha (FRA) overexpressing lung cancer cells. The targeted nanoparticle delivery also induced apoptosis, and demonstrated efficient combined therapeutic activity of CDDP and HuR siRNA in lung cancer cells.271
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Biomedical Engineering
Authors
Narsireddy PhD, Anish PhD, Janani PhD, Akhil PhD, Ranganayaki MS, Allshine MS, Yan D. PhD, Anupama PhD, Rajagopal PhD,