| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7238897 | Nanomedicine: Nanotechnology, Biology and Medicine | 2018 | 31 Pages |
Abstract
The IGF2R-specific peptide, cholesterol, and vitamin A are used as the targeting ligands for the neutravidin-based siRNA nanocomplex to deliver PCBP2 siRNA to fibrotic liver. Compared to free siRNA and the nanocomplexes coupled with vitamin A (SNVP) and cholesterol (SNCP), the IGF2R-specific peptide coupled nanocomplex (SNPP) showed the highest uptake in the liver and lowest uptake in the lung and kidney of the rats with CCl4-induced liver fibrosis. IGF2R-specific peptide modified nanocomplex is therefore a promising delivery platform for antifibrotic siRNAs.276
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Authors
Zhen MS, Yuanke MS, Akshay MS, Zhijin MS, Hao MS, Wei BS, Kun PhD,