| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 724043 | IFAC Proceedings Volumes | 2007 | 6 Pages |
Abstract
Integrated Bioprocesses as a direct technological link between methods for the cultivation of the yeast Pichia pastoris and additional down-stream procedures ranging from cross-flow filtration for product recovery up to purification with combined chromatography systems are developed for a fully automated production of recombinant pharmaceutical proteins. The set-up of an appropriate 40 l pilot plant with an extended Process Analytical Technology (PAT) for on-line monitoring of important process variables, e.g. the recombinant product, as well as the development of complex control strategies by means of Apparent Processing with a real-time simulation system are explained.
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Authors
R. Luttmann, M. Eicke, A. Kazemi, A. Ellert, B. Hahn, E. Werner,