Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
724097 | IFAC Proceedings Volumes | 2007 | 6 Pages |
Abstract
An extensive monitoring system is build up to fully automate and scan production processes of recombinant Escherichia coli for optimal process performance. It is based on in-line, on-line and at-line measurements for substrates and products. MATLABr is connected via OPC OPC Object linked and embedded (OLE) for process control to the SCADASCADA Supervisory control and data acquisition system MFCS/winr to realise on-line calculations of cell specific and volumetric reaction rates, based on the applied analytical systems. For on-line determination of intracellular target protein recombinant GFP is expressed either as single or fusion protein.
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Authors
C. Kaiser, T. Peuker, T. Bauch, A. Ellert, R. Luttmann,