Article ID Journal Published Year Pages File Type
726230 Journal of Electrostatics 2009 11 Pages PDF
Abstract
The application of appropriate electric fields to cells and tissues, termed electroporation, can result in efficient and safe gene transfer. We have shown previously that this approach results in high level gene transfer to and expression in the vasculature of living animals. This paper presents the results of an electric field distribution study of a rat mesenteric vasculature model using the Finite-Element Time-Domain (FETD) technique. A novelty of this work is the use of Debye dispersive dielectric parameters, as the electrical response of biological tissues is inherently frequency-dependent. The results compare fairly well with experimental findings.
Related Topics
Physical Sciences and Engineering Engineering Electrical and Electronic Engineering
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