Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7278554 | Biological Psychology | 2015 | 37 Pages |
Abstract
Our results suggest that two different sub-regions of the amygdala and their respective neural networks are affected in OCD: the superficial amygdala and networks related to evaluation of reinforcers and risk anticipation and the basolateral amygdala which is implicated in fear processing. The diminished CBT response in patients showing a lower degree centrality of the basolateral amygdala reflects a deficient fear circuit in these patients which may impact fear extinction as a core mechanism of exposure-based CBT.
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Authors
Martin Göttlich, Ulrike M. Krämer, Andreas Kordon, Fritz Hohagen, Bartosz Zurowski,