| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7279774 | Brain, Behavior, and Immunity | 2017 | 38 Pages |
Abstract
We show for the first time that the development of depression-like behavior in the SNI model requires brain IL-1 signaling and activation of neuronal KMO, while pain is independent of this pathway. Inhibition of KMO may represent a promising target for treating depression.
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Immunology
Authors
Geoffroy Laumet, Wenjun Zhou, Robert Dantzer, Jules D. Edralin, XiaoJiao Huo, David P. Budac, Jason C. O'Connor, Anna W. Lee, Cobi J. Heijnen, Annemieke Kavelaars,