| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7280255 | Brain, Behavior, and Immunity | 2016 | 48 Pages |
Abstract
Compared to HCs, the decreased NAAÂ +Â NAAG concentration in the left hippocampus of BD-I patients suggests a decreased neuronal integrity in this region. In addition we found a positive relation between microglial activation and neuronal integrity in vivo, corresponding to a differentiated microglial function where some microglia induce apoptosis while others stimulate neurogenesis.
Keywords
NaAN-acetylaspartateYMRSNAAGGPCMRSBD-IPCHROISPGRN-acetyl-aspartyl-glutamateVOIBipolar I disorderbipolar disorderNeuroinflammationMRIMagnetic resonance imagingPositron emission tomographyvolume of interestbody mass indexBMImagnetic resonance spectroscopyconfidence intervalPhosphocreatinephosphocholinemicroglial activationGray matterwhite matterCSFCerebrospinal fluidMini-International Neuropsychiatric InterviewPRESSYoung Mania Rating Scaleregion of interestMorphologyMINIPCRPETcreatinehealthy controlglycerophosphocholine
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Authors
Bartholomeus C.M. ('Benno') Haarman, Huibert Burger, Janine Doorduin, Remco J. Renken, Anita J. Sibeijn-Kuiper, Jan-Bernard C. Marsman, Erik F.J. de Vries, Jan Cees de Groot, Hemmo A. Drexhage, Richard Mendes, Willem A. Nolen,