Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7281491 | Brain, Behavior, and Immunity | 2014 | 8 Pages |
Abstract
There is evidence for a time-dependent variability in the HPA stress system with an increased cortisol stress response in the first year after diagnosis along with a more blunted HPA stress response and a diminished GCS in subsequent disease stages. Data underscore the highly dynamic nature of HPA axis regulation in the MS disease process, which could possibly relate to compensatory mechanisms within a cytokine-HPA axis feedback circuit model.
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Simone Kern, Nicolas Rohleder, Graeme Eisenhofer, Jan Lange, Tjalf Ziemssen,