Excessive compensatory recruitment as a compulsory neurophysiological mechanism in Very Early Alzheimer's Disease as compared to Mild Vascular Dementia and to age-matched normal controls

These findings suggest that the delayed P450 latencies found over pre-frontal and frontal regions in both patient populations, reflect the partial disconnection of their neuronal pathways from limbic structures. Specifically, in VEAD patients, this aspect, along with the abnormally high amplitudes found over parietal and occipital regions, support the conclusion that VEAD patients allocate much more cerebral physiological resources and effort to accomplish the memory workload tasks as opposed to age-matched normal controls and to MVD patients. As such, in VEAD, the excessive recruitment of compensatory neuronal pools becomes a compulsory neurophysiological mechanism to meet the demanding tasks of our Memory Workload Paradigm.