| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7299015 | Neurobiology of Learning and Memory | 2016 | 7 Pages |
Abstract
Age-related cognitive decline is a major concern in society. Here, I discuss recent evidence that shows an age-related modulation of gene transcription by epigenetic modifications. Epigenetic modifications, such as histone acetylation, is unbalanced in aging, with an increase in histone deacetylation, that limits the expression of plasticity-related genes. By modifying the balance towards histone acetylation, histone deacetylase inhibitors present a new pharmacological approach to ameliorate age-related cognitive deficits.
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Authors
Rosalina Fonseca,