| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7300652 | Neurobiology of Learning and Memory | 2013 | 10 Pages |
Abstract
- Methylphenidate (MPH) is the most prescribed psychoactive drug for children.
- Widely used for ADHD and cognition, its cellular mechanisms are poorly understood.
- MPH decreased NR1 and NR2B, but not NR2A subunits, in juvenile prefrontal cortex.
- MPH also decreased NMDAR-EPSCs but increased AMPAR-mediated short-term plasticity.
- MPH increased the probability of LTP induction, but had a small effect on LTD.
Keywords
Related Topics
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Neuroscience
Behavioral Neuroscience
Authors
Kimberly R. Urban, Yan-Chun Li, Wen-Jun Gao,