| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7300907 | Neurobiology of Learning and Memory | 2012 | 13 Pages |
Abstract
⺠Homer1 knockout mice display deficits in long term potentiation in the hippocampus. ⺠Gene delivery of Homer1c rescues the synaptic deficits of Homer1 knockout mice. ⺠The LTP rescue by Homer1c in Homer1 knockout mice is dependent on mGluR5 activation. ⺠Homer1c also rescues the spatial learning deficits found in Homer1 knockout mice. ⺠Homer1c gene transfer into neurons results in upregulation of mGluR5 in astrocytes.
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Authors
Hilary Gerstein, Kenneth O'Riordan, Sue Osting, Martin Schwarz, Corinna Burger,