Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7301081 | Neurobiology of Learning and Memory | 2011 | 8 Pages |
Abstract
⺠Intermittent ethanol vapor exposure resulted in escalated operant self-administration for ethanol during acute withdrawal in dependent animals. ⺠Chronic matrix metalloproteinase (MMP) inhibition during the dependence induction period and acute withdrawal post-dependence testing prevented escalated ethanol self-administration. ⺠Dependence-induced escalation was shown to be a learned, plasticity-dependent, response because acute MMP inhibition prevented escalated ethanol self-administration.
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Authors
Alexander W. Smith, Kathryn A. Nealey, John W. Wright, Brendan M. Walker,