| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7301093 | Neurobiology of Learning and Memory | 2011 | 11 Pages |
Abstract
⺠Induction of LTP at lateral (LPP) and medial (MPP) perforant path-CA3 synapses involves opioid and NMDA receptors, respectively. ⺠Associative PP-CA3 LTP is seen with intense coactivation of the alternate perforant pathway. ⺠Opioid receptor antagonists block associative MPP-CA3 LTP induced by coactivation of the LPP. ⺠NMDAR antagonists block associative LPP-CA3 LTP induced by intense coactivation of the MPP. ⺠Opioid peptides contained in opioidergic afferents contribute to the associative induction of NMDAR-dependent LTP.
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Authors
Carlo O. Martinez, Viet H. Do, Brian E. Derrick,