Forebrain-specific constitutively active CaMKKÎ± transgenic mice show deficits in hippocampus-dependent long-term memory

Article ID	Journal	Published Year	Pages	File Type
7301117	Neurobiology of Learning and Memory	2011	10 Pages	PDF

Abstract

âº We created forebrain-specific constitutive active CaMKKÎ± transgenic mice. âº Phosphorylation of CaMKI was increased in these mice. âº These mice showed impairment in long-term spatial memory in the Barnes circular maze. âº Long-term memory in the contextual fear conditioning was also impaired in these mice.

Keywords

CREB cyclic AMP-responsive element binding protein CaM kinase kinase CaM kinase IV CaMKI PGC-1 CaMKK CaMKIV L-LTP PKB CaMKIIα E-LTP aCSF AMPK BDNF Ca2+/calmodulin long-term potentiation LTP Contextual fear conditioning CAM Brain-derived neurotrophic factor artificial cerebrospinal fluid unconditioned stimulus conditioned stimulus peroxisome proliferator-activated receptor gamma coactivator 1 protein kinase B 5′ adenosine monophosphate-activated protein kinase Spatial learning