Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7301292 | Neurobiology of Learning and Memory | 2011 | 11 Pages |
Abstract
⺠CMP X and CMP Y are two novel and highly selective 5-HT6 receptor antagonists. ⺠CMP X and CMP Y improved scopolamine-induced deficits in tests for episodic memory. ⺠Donepezil and reference 5-HT6 antagonist GSK-742457 also improved performance. ⺠Co-adm. of CMP X, CMP Y with donepezil resulted in additive cogn. enhancing effects. ⺠5-HT6 antagonists could have potential as adjunctive therapy to donepezil.
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Authors
N.M.W.J. de Bruin, J. Prickaerts, A. van Loevezijn, J. Venhorst, L. de Groote, P. Houba, O. Reneerkens, S. Akkerman, C.G. Kruse,