Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7302185 | Neuroscience & Biobehavioral Reviews | 2018 | 54 Pages |
Abstract
Response inhibition has been shown to be associated with monoamine-related gene polymorphisms, although evidence is inconclusive. To comprehensively examine these genotype effects on behavioural correlates of response inhibition in non-clinical adult populations, we performed a two-step approach. A systematic review of studies using Go/No-Go and/or Stop-Signal paradigms was first carried out. Thirty-eight eligible research articles were identified, which examined over 15 candidate genes. Remarkably, no firm conclusions could be drawn from these studies. Thus, in a second step, we conducted meta-analyses using random effects models on those polymorphisms that had previously been investigated in at least three studies. Specifically, data from 11 studies was analysed in three meta-analyses for the following polymorphisms: SLC6A3 3â²UTR VNTR (k = 6 samples; n = 1463 participants), COMT Val158Met SNP (k = 7 samples; n = 784) and SLC6A4 5-HTTLPR (k = 4 samples, n = 204). None of these polymorphisms showed a reliable association with response inhibition performance. The methodological and theoretical implications of these findings are discussed, along with recommendations for future research.
Related Topics
Life Sciences
Neuroscience
Behavioral Neuroscience
Authors
Irene Rincón-Pérez, Alberto J. Sánchez-Carmona, Jacobo Albert, José A. Hinojosa,