Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7303244 | Neuroscience & Biobehavioral Reviews | 2015 | 9 Pages |
Abstract
Vagus nerve stimulation (VNS) is a proposed neuromodulatory treatment for medically refractory major depression. Although VNS is already used in clinical practice, the underlying mechanism of action remains unknown. The present review provides an overview of the preclinical VNS studies in view of two major hypotheses in depression research: the monoaminergic and the neural plasticity hypothesis of depression.
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Authors
Annelies Grimonprez, Robrecht Raedt, Chris Baeken, Paul Boon, Kristl Vonck,