Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7303436 | Neuroscience & Biobehavioral Reviews | 2015 | 21 Pages |
Abstract
Considerable evidence suggests that MDD is associated with impaired brain signals of reward prediction error and expected value ('wanting'), decreased reward sensitivity ('liking') and/or learning (be it model-free or model-based), etc., although the causality remains unclear. These parameters may serve as valuable intermediate phenotypes of MDD, linking general clinical symptoms to underlying molecular dysfunctions. We believe future computational research at clinical, systems, and cellular/molecular/genetic levels will propel us toward a better understanding of the disease.
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Behavioral Neuroscience
Authors
Chong Chen, Taiki Takahashi, Shin Nakagawa, Takeshi Inoue, Ichiro Kusumi,