Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7303640 | Neuroscience & Biobehavioral Reviews | 2015 | 9 Pages |
Abstract
- Developmental delays are common to many monogenic intellectual disability and autistic disorders.
- Animal models reveal delayed and transient impairments at the level of the synapse.
- Many impairments occur within known critical periods for normal brain development.
- Temporal expression patterns of affected genes may underlie developmental phenotypes directly or indirectly.
- Dysregulated critical periods could unify other key hypotheses underlying these disorders.
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Authors
R.M. Meredith,