Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7304120 | Neuroscience & Biobehavioral Reviews | 2014 | 12 Pages |
Abstract
This study does not support the association between SNP rs6265 and hippocampal volume in healthy individuals. The weakly significant effect observed in the meta-analysis is mainly driven by studies with small sample sizes. In contrast, our original data and the meta-analysis of automatically segmented hippocampal volumes, which was based on studies with large samples sizes, revealed no significant genotype effect. Thus, meta-analyses of the association between rs6265 and hippocampal volumes should consider possible biases related to measuring technique and sample size.
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Authors
F. Harrisberger, K. Spalek, R. Smieskova, A. Schmidt, D. Coynel, A. Milnik, M. Fastenrath, V. Freytag, L. Gschwind, A. Walter, T. Vogel, K. Bendfeldt, D.J.-F. de Quervain, A. Papassotiropoulos, S. Borgwardt,