Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7374887 | Physica A: Statistical Mechanics and its Applications | 2018 | 9 Pages |
Abstract
We use a one-dimensional two layer model with a semi-permeable membrane to study the diffusion of a therapeutic drug delivered from a drug-eluting stent (DES). The rate of drug transfer from the stent coating to the arterial wall is calculated by using underdamped Langevin dynamics simulations. Our results reveal that the membrane has virtually no delay effect on the rate of delivery from the DES. The work demonstrates the great potential of underdamped Langevin dynamics simulations as an easy to implement, efficient, method for solving complicated diffusion problems in systems with a spatially-dependent diffusion coefficient.
Related Topics
Physical Sciences and Engineering
Mathematics
Mathematical Physics
Authors
Shaked Regev, Oded Farago,