| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7382075 | Physica A: Statistical Mechanics and its Applications | 2014 | 27 Pages |
Abstract
In this paper, a network of hypertension-related genes is constructed by analyzing the correlations of gene expression data among the Dahl salt-sensitive rat and two consomic rat strains. The numerical calculations show that this sparse and assortative network has small-world and scale-free properties. Further, 16 key hub genes (Col4a1, Lcn2, Cdk4, etc.) are determined by introducing an integrated centrality and have been confirmed by biological/medical research to play important roles in hypertension.
Keywords
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Physical Sciences and Engineering
Mathematics
Mathematical Physics
Authors
Huan Wang, Chuan-Yun Xu, Jing-Bo Hu, Ke-Fei Cao,