Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7503085 | Drug and Alcohol Dependence | 2018 | 42 Pages |
Abstract
There were no differences between male and female rats in context-induced reinstatement of alcohol-seeking behavior. Re-exposure to Context A, but not Context B, reinstated alcohol-seeking behavior and increased expression of the neural activity marker Fos in the OFC. Reversible inactivation of the OFC with muscimol and baclofen attenuated context-induced reinstatement. Our data indicated that the OFC mediates context-induced reinstatement of alcohol-seeking behavior.
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Authors
Paula Cristina Bianchi, Paulo Eduardo Carneiro de Oliveira, Paola Palombo, Rodrigo Molini Leão, Hugo Cogo-Moreira, Cleopatra da Silva Planeta, Fábio Cardoso Cruz,