| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7503663 | Drug and Alcohol Dependence | 2016 | 24 Pages |
Abstract
These results, which are consistent with cannabidiol lacking CB1 receptor agonist or antagonist activity in vivo, demonstrate enhancement of the effects of Î9-THC by cannabidiol, albeit at cannabidiol amounts larger than those in Cannabis or cannabidiol-based therapeutics (nabiximols). In addition to showing that cannabidiol and a 5-HT1A receptor agonist have overlapping behavioral effects, the current results suggest that 5-HT1A agonism enhances the CB1 receptor-mediated effects of Î9-THC.
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Authors
Lance R. McMahon,