| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7504501 | Drug and Alcohol Dependence | 2015 | 11 Pages |
Abstract
Present data firstly demonstrate the influence of drug addiction with known heroin abuse on different developmental stages of progenitors in the dentate gyrus. The patterns of antibody staining suggest a distinct inhibition of neurogenesis at the stage of neural precursor cells and revealed morphological changes in targeting cells in cases of heroin addicts as compared to healthy controls. These alterations could be considerable for memory and cognitive deficits as well as addictive behaviour in chronic drug abusers and may give rise to specific pro-neurogenic therapies.
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Authors
Ronny Bayer, Heike Franke, Christoph Ficker, Monique Richter, Rüdiger Lessig, Andreas Büttner, Marco Weber,