Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7505072 | Drug and Alcohol Dependence | 2015 | 5 Pages |
Abstract
These findings indicate that some minor tobacco alkaloids can either fully (nornicotine, anabasine) or partially (myosmine) mimic nicotine's addiction-related effects on ICSS, albeit at reduced potency. These findings emphasize the need for further study of the abuse potential of minor alkaloids, including evaluation of their effects when combined with nicotine and other tobacco constituents to better simulate tobacco exposure in humans. Such work is essential for informing FDA regulation of tobacco products and could also lead to the development of novel pharmacotherapies for tobacco addiction.
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Authors
Andrew C. Harris, Laura Tally, Peter Muelken, Andrew Banal, Clare E. Schmidt, Qing Cao, Mark G. LeSage,