Article ID Journal Published Year Pages File Type
7507729 Drug and Alcohol Dependence 2013 8 Pages PDF
Abstract
The present findings suggest that METH compromises frontal lobe high-energy phosphate metabolism in a dose-responsive manner. Our findings also suggest that the abnormality in frontal lobe high-energy phosphate metabolism might be more prominent in female than in male METH users. This is significant as decreased PCr levels have been associated with depressive symptoms, and poor responses to antidepressant treatment have been reported in those with decreased PCr levels.
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Life Sciences Neuroscience Behavioral Neuroscience
Authors
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