Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
7507827 | Drug and Alcohol Dependence | 2012 | 8 Pages |
Abstract
The present findings demonstrate that METH self-administration alters serotonergic neurons so as to engender “tolerance” to the persistent serotonergic deficits caused by a subsequent METH exposure. However, this “tolerance” does not persist. These data provide a foundation to investigate complex questions including how the response of serotonergic neurons to METH may contribute to contingent-related disorders such as dependence and relapse.
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Authors
Lisa M. McFadden, Madison M. Hunt, Paula L. Vieira-Brock, Janice Muehle, Shannon M. Nielsen, Scott C. Allen, Glen R. Hanson, Annette E. Fleckenstein,