| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 7508125 | Drug and Alcohol Dependence | 2012 | 5 Pages |
Abstract
The mGlu5 receptor (mGluR5) has been implicated in the rewarding effect of various drugs of abuse and drug-seeking behaviour. In the present study we investigated the impact of antagonism of mGluR5 with the selective negative allosteric, modulator 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) on operant self-administration of morphine as well as cue-induced drug-seeking in adult CD1 mice. Administration of MTEP (20Â mg/kg, i.p.) attenuated operant responding for morphine (0.1Â mg/kg/infusion) and cue-induced morphine-seeking after a period of forced abstinence. Collectively, these data implicate mGluR5 in the reinforcing effects of opiates and support the proposition that mGluR5 is a potential therapeutic target for treatment of drug addiction.
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Authors
Robyn M. Brown, Monique R. Stagnitti, Jhodie R. Duncan, Andrew J. Lawrence,